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Surfactant Depletion Combined with Injurious Ventilation Results in a Reproducible Model of the Acute Respiratory Distress Syndrome (ARDS)
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Surfactant Depletion Combined with Injurious Ventilation Results in a Reproducible Model of the Acute Respiratory Distress Syndrome (ARDS)

Published on: April 7, 2021

Pediatric ARF epidemiology at a tertiary care center from 1999 to 2001

Shirley Hui-Stickle1, Eileen D Brewer, Stuart L Goldstein

  • 1Baylor College of Medicine and Texas Children's Hospital, Houston, TX 77030, USA. stuartg@bcm.tmc.edu

American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation
|February 8, 2005
PubMed

Insights

Pediatric acute renal failure (ARF) is now more commonly caused by systemic illness rather than primary kidney disease. Survival rates for pediatric ARF vary, with lower survival for those requiring intensive care or renal replacement therapy.

Area of Science:

  • Pediatric Nephrology
  • Critical Care Medicine
  • Epidemiology

Background:

  • Existing pediatric acute renal failure (ARF) data predate modern intensive care unit (ICU) advancements.
  • Current data do not reflect outcomes with newer therapies for transplantation and congenital heart disease surgery.

Purpose of the Study:

  • To update epidemiological characteristics of pediatric ARF.
  • To analyze current causes and outcomes of ARF in children.

Main Methods:

  • Retrospective review of 254 ARF episodes in 248 children.
  • Data collected from a tertiary referral center between January 1998 and June 2001.

Main Results:

  • Leading causes of pediatric ARF identified as renal ischemia (21%), nephrotoxic medications (16%), and sepsis (11%).
  • Primary renal diseases and hemolytic uremic syndrome were infrequent causes.
  • Overall ARF survival was 70% (176/254); survival was 60% for ICU patients and 56% for those on renal replacement therapy.

Conclusions:

  • Pediatric ARF epidemiology has shifted from primary renal disease to secondary renal involvement in systemic illness.
  • Longitudinal studies are planned to assess long-term consequences of pediatric ARF.
Abstract

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