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Published on: September 8, 2021
[Association of schizophrenia with a promoter polymorphism in the dopamine D2 receptor gene]
Dai-hui Peng1, Gao-hua Wang, Zi-li Cheng
1Department of Psychiatry, Renmin Hospital of Wuhan University, Wuhan, Hubei, 430060 PR China. pengdaihui@21cn.com
Objective:
To investigate the association of -141C insert/delete polymorphism with schizophrenia in Wuhan of Hubei province.
Methods:
A case-control study was conducted to analyze the polymorphism in the D(2) receptor gene promoter region with schizophrenia. A total of 120 cases of schizophrenia diagnosed according to CCMD-II R criteria and 100 normal controls were recruited in the study.
Results:
In this sample, the allele and genotype showed statistically significant differences between patients and normal controls (P<0.05).Especially, the frequency of -141C del was 11% in patients and 18% in control(OR 0.55, 95% CI 0.30-0.96; P<0.05). This allele was less common in schizophrenia than in normal controls (P<0.05).
Conclusion:
The -141C del polymorphism is associated with schizophrenia.The polymorphism may modify the association with other factors. Possibly -141C del in the DRD(2) promoter region is a strong candidate for a protective factor for this trait.
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