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Related Experiment Videos

Ascorbic acid overdosing: a risk factor for calcium oxalate nephrolithiasis.

M Urivetzky1, D Kessaris, A D Smith

  • 1Department of Urology, Long Island Jewish Medical Center, New Hyde Park, New York.

The Journal of Urology
|May 1, 1992
PubMed
Summary
This summary is machine-generated.

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High-dose ascorbic acid (vitamin C) supplements significantly increase urinary oxalate levels. This elevation may heighten the risk of developing calcium oxalate urolithiasis (kidney stones).

Area of Science:

  • Biochemistry
  • Nephrology
  • Urology

Background:

  • Ascorbic acid (vitamin C) is a common supplement with potential metabolic effects.
  • Understanding its impact on urinary stone risk factors is crucial for patient care.

Purpose of the Study:

  • To investigate the effect of varying doses of ascorbic acid on urinary oxalate excretion.
  • To determine if ascorbic acid supplementation increases the risk of calcium oxalate urolithiasis.

Main Methods:

  • 15 patients with unilateral nephrostomy tubes post-lithotripsy received placebo or 100-2,000 mg ascorbic acid.
  • Urine samples were collected directly from both kidneys over 6-hour periods.
  • Urinary oxalate was measured enzymatically after stabilization with preservatives.

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Main Results:

  • Preservatives were essential for accurate oxalate recovery.
  • Doses of 500 mg or more of ascorbic acid significantly increased urinary oxalate.
  • This increase represented 6-13 mg oxalate/day per 1,000 mg ascorbic acid supplement.

Conclusions:

  • Ascorbic acid supplementation, particularly at higher doses, elevates urinary oxalate.
  • This biochemical change may increase the risk of calcium oxalate kidney stone formation.