[Morphological and immunohistochemical quantitative analysis of dysplasia in ulcerative colitis. 1. Histological...

Mapping specimens of 6 cases of ulcerative colitis included adenocarcinoma invaded into submucosa (invasive carcinoma) were made and Index value of Nucleus-Gland (ING) of invasive carcinoma, severe and moderate dysplasia in ulcerative colitis was measured and compared with one another. Large intestinal carcinoma invaded into submucosa, colonic adenoma and normal mucosa were examined as the control. Spatial relations of invasive carcinoma and dysplasia in ulcerative colitis were also examined. Severe and moderate dysplasia as well as large intestinal carcinoma invaded into submucosa showed significantly higher values of ING than adenoma (P less than 0.01). Invasive carcinoma and severe dysplasia of ulcerative colitis showed significantly higher values of ING than moderate dysplasia (P less than 0.01). Severe dysplasia was located around the portion of of invasive carcinoma of ulcerative colitis. Severe dysplasia falls into the same category with invasive carcinoma of ulcerative colitis because of the same value of ING and spatial translation each other. Moderate dysplasia was defined as borderline lesion because of the mean value of ING between severe dysplasia and adenoma.