Related Experiment Video
Updated: Jul 22, 2026
17:03
Direct Observation of Enzymes Replicating DNA Using a Single-molecule DNA Stretching Assay
Published on: March 23, 2010
Conformation and dynamics of single DNA molecules in parallel-plate slit microchannels
Y-L Chen1, M D Graham, J J de Pablo
1Department of Chemical and Biological Engineering, University of Wisconsin-Madison, Madison, Wisconsin 53703, USA.
Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics
|February 9, 2005
Abstract:
The conformation and diffusion of a single DNA molecule confined between two parallel plates are examined using both single molecule experiments and Brownian dynamics simulations accounting for hydrodynamic interactions. The degree of chain stretching and the diffusivity are characterized as a function of the chain confinement and the channel geometry. Good agreement is found between the simulations, experiments, and scaling theory predictions.
