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Related Experiment Video

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Investigating Mammalian Axon Regeneration: In Vivo Electroporation of Adult Mouse Dorsal Root Ganglion

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Published on: September 1, 2018

Axonal oscillations in developing mammalian nerve axons.

Shangyou Zeng¹, Peter Jung

¹Department of Physics and Astronomy and Quantitative Biology Institute, Ohio University, Athens, Ohio 45701, USA.

Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics

|February 9, 2005

Summary

Axonal bursting in developing nerves can occur without potassium channels due to backfiring at nodes of Ranvier or changes in myelin thickness. This computational study explores the mechanisms behind this neuronal phenomenon.

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Mechanical Manipulation of Neurons to Control Axonal Development

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Published on: April 10, 2011

Area of Science:

Neuroscience
Computational Biology
Axonal Development

Background:

Axonal bursting, a form of neuronal oscillation, has been observed in developing nerves.
This phenomenon occurs in the absence of potassium channels, prompting further investigation into its underlying mechanisms.

Purpose of the Study:

To computationally model neuronal spike propagation in developing myelinated axons.
To explore the conditions under which axonal bursting can occur in developing nerves.

Main Methods:

Detailed computational modeling of myelinated axons at various developmental stages.
Simulations focused on neuronal spike propagation and axonal oscillation.

Main Results:

Axonal oscillation can be induced by backfiring between nodes of Ranvier.
Backfiring from internodal sodium channels can also cause axonal bursting.
Reduced myelin wrapping thickness between nodes of Ranvier contributes to axonal oscillation.

Conclusions:

Computational models can elucidate mechanisms of axonal bursting in developing nervous systems.
Identified mechanisms include nodal backfiring, internodal sodium channel activity, and myelin sheath alterations.
Findings provide insights into the electrophysiological development of axons.