Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Perfusion and diffusion MR imaging.

M D King1, N van Bruggen, A L Busza

  • 1Department of Biophysics, Hunterian Institute, Royal College of Surgeons of England, London, United Kingdom.

Magnetic Resonance in Medicine
|April 1, 1992
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Monitoring airborne pathogen transmission for enhanced safety at food processing facilities.

Acta alimentaria·2026
Same author

Atlantic water intrusion triggers rapid retreat and regime change at previously stable Greenland glacier.

Nature communications·2023
Same author

Uniparental disomy screen of Irish rare disorder cohort unmasks homozygous variants of clinical significance in the <i>TMCO1</i> and <i>PRKRA</i> genes.

Frontiers in genetics·2022
Same author

Correction to: Spectrum of movement disorders and neurotransmitter abnormalities in paediatric POLG disease.

Journal of inherited metabolic disease·2018
Same author

Spectrum of movement disorders and neurotransmitter abnormalities in paediatric POLG disease.

Journal of inherited metabolic disease·2018
Same author

SCN1A Variant and Cannabidiol Use.

Irish medical journal·2018

Researchers attempted to extract brain perfusion parameters from diffusion-weighted images but found the Le Bihan method lacked accuracy. While qualitative information was present, quantitative perfusion parameters were not reliably obtained.

Area of Science:

  • Neuroimaging
  • Biophysics
  • Medical Physics

Background:

  • Diffusion-weighted imaging (DWI) is a key MRI technique for assessing water molecule diffusion in biological tissues.
  • Accurate measurement of brain perfusion parameters is crucial for diagnosing and monitoring neurological conditions.
  • The Le Bihan biexponential model is a commonly used approach to analyze DWI data for perfusion estimation.

Purpose of the Study:

  • To evaluate the feasibility of extracting quantitative perfusion parameters from rat brain DWI using the Le Bihan model.
  • To assess the accuracy and reliability of the Le Bihan biexponential fit for perfusion quantification.
  • To analyze the limitations of the Le Bihan model in measuring pseudo-diffusion coefficients.

Main Methods:

  • Acquisition of diffusion-weighted images (DWI) of the rat brain using the pulsed-gradient spin-echo (PGSE) sequence.

Related Experiment Videos

  • Application of a nonlinear least-squares fitting algorithm to the caudate-putamen signal intensity data.
  • Fitting the Le Bihan biexponential model to the DWI signal decay curve to extract perfusion parameters.

    • Main Results:

    • Quantitative perfusion-related parameters could not be extracted with sufficient accuracy for clinical utility.
    • Perfusion-weighted images derived from the method contained meaningful qualitative information about brain perfusion.
    • Analysis revealed significant challenges in accurately measuring the Le Bihan pseudo-diffusion coefficient.

    Conclusions:

    • The Le Bihan biexponential model, when applied to rat brain DWI, is not sufficiently accurate for reliable quantitative perfusion parameter extraction.
    • Qualitative assessment of perfusion from DWI is possible, but quantitative analysis remains challenging.
    • Further refinement of DWI models and fitting techniques is necessary for accurate perfusion quantification.