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Isolation of Functional Cardiac Immune Cells
Published on: December 5, 2011
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Tumor necrosis factor-alpha receptor 1 is a major predictor of mortality and new-onset heart failure in patients with
Marco Valgimigli1, Claudio Ceconi, Patrizia Malagutti
1Chair of Cardiology, University of Ferrara Cardiovascular Institute, Arcispedale S. Anna, C.rso Giovecca 203, 44100 Ferrara, Italy. vlgmrc@unife.it
Circulation
|February 9, 2005
Summary
Soluble tumor necrosis factor receptor 1 (sTNFR-1) predicts mortality and heart failure (HF) after myocardial infarction. This finding offers crucial insights for managing post-heart attack patient outcomes.
Area of Science:
- Cardiovascular Medicine
- Immunology
- Biomarkers
Background:
- Tumor necrosis factor alpha (TNF-alpha) activation is linked to mortality in heart failure (HF).
- Cytokine roles in predicting prognosis after myocardial infarction (MI) are not fully understood.
Purpose of the Study:
- To evaluate TNF-alpha, its soluble receptors, and other cytokines as predictors of death and HF post-MI.
- To identify independent prognostic markers in acute myocardial infarction patients.
Main Methods:
- Systematic evaluation of TNF-alpha, sTNFR-1, sTNFR-2, IL-6, IL-1RA, and IL-10 in 184 MI patients.
- Correlation of cytokine levels with short- and long-term incidence of death and HF.
- Analysis of transcardiac gradients for TNF-alpha and its receptors in a subset of patients.
Main Results:
- All tested cytokines were elevated in MI patients compared to controls.
- After a median follow-up of 406 days, 24 patients died and 32 developed HF.
- Soluble TNFR-1 (sTNFR-1) was the sole independent predictor of death and HF, alongside traditional clinical factors.
Conclusions:
- Soluble TNFR-1 (sTNFR-1) is a significant predictor of mortality and HF in acute myocardial infarction.
- sTNFR-1 provides valuable prognostic information for patients following MI.
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