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Diffuse global granulomatous glomerulonephritis in a pig.
Akihiko Sugiyama1, Kiyokazu Ozaki, Isao Narama
1Osaka City Meat Inspection Office, Nankominami, Suminoe-ku, Osaka, Japan.
The Journal of Veterinary Medical Science
|February 9, 2005
Summary
A unique case of granulomatous glomerulonephritis was found in a pig, characterized by severe inflammation and basement membrane destruction. Pathogen testing, including for PRRSV and PCV-2, was negative.
Area of Science:
- Veterinary Pathology
- Nephrology
- Immunohistochemistry
Background:
- Diffuse global granulomatous glomerulonephritis is a rare renal disease.
- Understanding its unique morphological features and potential causes is crucial for diagnosis.
Purpose of the Study:
- To describe a unique case of granulomatous glomerulonephritis in a pig.
- To investigate the underlying causes through morphological and etiological examinations.
Main Methods:
- Gross and histopathological examination of renal tissue.
- Immunohistochemical staining for Porcine Reproductive and Respiratory Syndrome Virus (PRRSV) and Porcine Circovirus type 2 (PCV-2).
- Ziel-Neelsen staining for acid-fast bacilli and bacterial culture.
Main Results:
- The pig exhibited diffuse global glomerulonephritis with destroyed glomerular basement membranes.
- Severe infiltration of macrophages into glomeruli, Bowman's space, and interstitium was observed.
- Periarteritis with fibrinoid necrosis was noted in renal arterioles.
- Immunohistochemistry and bacterial cultures were negative for common pathogens.
Conclusions:
- The case presents a distinct form of granulomatous glomerulonephritis in a pig.
- The etiology remains undetermined despite extensive testing, highlighting the need for further research into novel causes of renal disease in swine.