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Intracranial localized Castleman's disease. Case report.
Ken-ichi Matsumura1, Satoshi Nakasu, Toshiki Tanaka
1Department of Neurosurgery, Kusatsu General Hospital, Kusatsu, Shiga, Japan. mm-happy@estate.ocn.ne.jp
Neurologia Medico-Chirurgica
|February 9, 2005
Summary
Castleman
Area of Science:
- Neurology
- Oncology
- Pathology
Background:
- Castleman's disease is a rare lymphoproliferative disorder.
- Central nervous system involvement is exceptionally rare, with limited documented cases.
Observation:
- A 68-year-old woman presented with neurological deficits and a seizure.
- Imaging revealed a meningeal-like mass with significant edema.
- Cerebral angiography suggested a meningioma vascular supply.
Findings:
- Histopathology confirmed hyaline-vascular Castleman's disease.
- The intracranial lesion mimicked a meningioma on imaging.
- Complete surgical resection led to full recovery and no recurrence.
Implications:
- Castleman's disease should be considered in the differential diagnosis of intracranial meningeal tumors.
- Surgical resection is an effective treatment for localized CNS Castleman's disease.
- This case expands the understanding of rare neurological manifestations of Castleman's disease.