Related Experiment Video
Updated: Aug 19, 2026

Strategies for Tracking Anastasis, A Cell Survival Phenomenon that Reverses Apoptosis
Published on: February 16, 2015
Mature B cells: apoptosis checkpoints
1INSERM U404, 69365 Lyon, Cedex 04, France. defrance@cervi-lyon.inserm.fr
Abstract:
In the present review, the apoptosis mechanisms that ensure efficiency of the B cell responses and homeostasis of mature B cells are examined. The general scheme that emerges from the literature is that these two phenomena are under the control of distinct apoptotic pathways. The extrinsic death receptor pathway intervenes in the quality control of the B cell response to thymus-dependent antigens. It prevents the bystander activation of irrelevant B cell clones and is instrumental in the affinity maturation of the antibody response. The intrinsic death pathway is responsible for homeostasis of the naive, effector, and memory B cell compartments. Recent results suggest the stress signal that triggers this pathway may be initiated by different cellular organelles depending on the B cell developmental stage.
Related Concept Videos
Cellular Injury V: Apoptosis and Autophagy
The Intrinsic Apoptotic Pathway
Apoptosis
The Extrinsic Apoptotic Pathway
Phagocytosis of Apoptotic Cells
Normal cells contain receptors that prevent them from being recognized by phagocytes.
Overview of Cell Death
Cell death was observed in the early 19th century, but there was no experimental evidence to prove it. In 1842, Carl Vogt first discovered cell death in a metamorphic toad; however, it was not termed ‘cell death.’ Scientists discovered different cell death pathways only in the 20th century...

