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Nutritional markers in liver allograft recipients
Mohammad Shahid1, Jill Johnson, Peter Nightingale
1St. Bartholomew's and The Royal London School of Medicine and Dentistry, Queen Mary College, University of London, London, UK.
Transplantation
|February 9, 2005
Summary
Malnutrition in liver transplant candidates does not strongly predict post-transplant outcomes. Nutritional status markers showed weak correlations with survival, suggesting limited impact on overall results for end-stage liver disease patients.
Area of Science:
- Hepatology
- Transplantation Medicine
- Nutritional Science
Background:
- Malnutrition is prevalent in end-stage liver disease (ESLD) patients awaiting liver transplantation.
- The impact of pre-transplant malnutrition on post-transplant outcomes remains unclear.
Purpose of the Study:
- To investigate the relationship between malnutrition severity and outcomes in liver transplant recipients.
- To assess if nutritional parameters predict post-transplant success in ESLD patients.
Main Methods:
- Prospective study involving 61 patients with chronic liver disease undergoing transplantation.
- Evaluation of nutritional parameters including mid-arm circumference (MAC), hand-grip strength, and triceps skin-fold thickness (TSFT).
- Correlation analysis with clinical severity scores like Child-Pugh and Model for End-Stage Liver Disease (MELD).
Main Results:
- Weak correlations were observed between Child-Pugh/MELD scores and MAC, but not other nutritional markers.
- Child-Pugh score, but not MELD, was linked to intensive therapy unit stay.
- Weak correlations found between mortality and MAC and TSFT.
Conclusions:
- Nutritional parameters and disease severity markers show poor correlation with post-transplant outcomes.
- Current nutritional assessments may not reliably predict outcomes in liver transplant recipients.
