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Updated: Jul 15, 2026
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Porcine Liver Transplantation Without Veno-Venous Bypass As an Extended Criteria Donor Model
Published on: August 17, 2022
Living donor liver transplant for malignancy
David Axelrod1, Alan Koffron, Laura Kulik
1Division of Transplant Surgery, Department of Surgery, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.
Transplantation
|February 9, 2005
Summary
Adult-to-adult living donor liver transplantation (ALDLT) offers a viable option for advanced liver cancers. While safe overall, hepatocellular carcinoma recurrence is high, but cholangiocarcinoma shows promise with neoadjuvant therapy.
Area of Science:
- Hepatobiliary surgery
- Transplant oncology
- Surgical oncology
Background:
- Adult-to-adult living donor liver transplantation (ALDLT) is increasingly used for advanced liver malignancies.
- Patients with hepatocellular carcinoma (HCC) and cholangiocarcinoma often exceed MELD allocation criteria.
Purpose of the Study:
- To review indications, complications, and outcomes of ALDLT for malignancy.
- To evaluate the safety and efficacy of ALDLT in treating advanced liver cancers.
Main Methods:
- Retrospective chart review of ALDLTs performed for malignancy.
- Analysis of 18 cases performed since 1997.
Main Results:
- Thirteen patients underwent ALDLT for HCC; median survival was 18.6 months, with 4 recurrences.
- Five patients underwent ALDLT for cholangiocarcinoma; 100% recurrence-free survival with neoadjuvant chemoradiation.
- ALDLT demonstrated acceptable peri-operative mortality for malignancy.
Conclusions:
- ALDLT is a safe procedure for liver malignancy with acceptable mortality.
- Hepatocellular carcinoma patients with large tumors face high recurrence rates post-ALDLT.
- ALDLT for cholangiocarcinoma, especially with neoadjuvant therapy, shows promising outcomes.
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