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Fine-tuning furan toxicity: fast and quantitative DNA interchain cross-link formation upon selective oxidation of a
Sami Halila1, Trinidad Velasco, Pierre De Clercq
1Laboratory for Organic and Biomimetic Chemistry, Department of Organic Chemistry, Krijgslaan 281, S4, 9000, Gent, Belgium.
Chemical Communications (Cambridge, England)
|February 9, 2005
Abstract:
Oligonucleotides containing a furan modified internal nucleoside have been synthesized; selective in situ oxidation of the furan moiety to a reactive enal species in the presence of a complementary DNA strand gives rise to fast and efficient formation of an interstrand cross-link.
