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Ewing sarcoma as a second malignant neoplasm after acute lymphoblastic leukemia.
Grace E Kim1, Barbara Beach, Julie M Gastier-Foster
1UCSF Children's Hospital, San Francisco, California 94143-0106, USA.
Pediatric Blood & Cancer
|February 9, 2005
Summary
Second malignant neoplasms (SMNs) are increasingly recognized. This case highlights an unusual occurrence of Ewing sarcoma as an SMN in an acute lymphoblastic leukemia (ALL) survivor treated without radiation.
Area of Science:
- Oncology
- Pediatric Hematology-Oncology
- Cancer Survivorship
Background:
- Second malignant neoplasms (SMNs) are a growing concern in cancer survivors.
- Acute lymphoblastic leukemia (ALL) survivors treated without radiation are at lower risk for certain SMNs.
- The development of specific secondary cancers, like Ewing sarcoma, is rare in these patients.
Observation:
- A 7-year-old girl with a history of ALL presented with a humerus mass.
- Diagnostic evaluation revealed the mass to be Ewing sarcoma.
- This represents a rare instance of a secondary cancer in an ALL survivor.
Findings:
- The patient developed Ewing sarcoma as a second malignant neoplasm.
- This occurred despite receiving ALL treatment without radiation therapy.
- The occurrence of Ewing sarcoma as an SMN is highly unusual.
Implications:
- This case underscores the importance of long-term surveillance for SMNs in ALL survivors.
- It highlights the potential for rare secondary cancers even after non-radiation-based therapy.
- Further research may be needed to understand the specific risk factors for developing Ewing sarcoma as an SMN.