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Hemispheric supratentorial low-grade astrocytoma.
E Reichenthal1, Z Feldman, M L Cohen
1Department of Neurosurgery, Beilinson Medical Center, Sackler School of Medicine, Tel-Aviv University, Israel.
Neurochirurgia
|January 1, 1992
Summary
Younger age and negative isotope scans predict better survival for supratentorial low-grade astrocytomas. Extensive resection and radiation therapy also improved patient outcomes.
Area of Science:
- Neurosurgery
- Oncology
- Neuropathology
Background:
- Supratentorial low-grade astrocytomas are primary brain tumors.
- Long-term patient management and survival factors require further investigation.
Purpose of the Study:
- To correlate patient management strategies with survival rates for supratentorial low-grade astrocytomas.
- To identify key prognostic factors influencing survival in these patients.
Main Methods:
- Retrospective review of 57 patients operated on for supratentorial low-grade astrocytomas between 1970 and 1982.
- Correlation of management approaches, including surgical resection and radiation therapy, with patient survival data.
Main Results:
- Younger age at diagnosis was significantly associated with improved survival.
- Negative radionuclide uptake on isotope scans was a key indicator of better prognosis.
- Extensive tumor resection combined with radiation therapy demonstrated a beneficial effect on survival duration.
Conclusions:
- Age at onset and preoperative diagnostic findings are critical prognostic indicators for low-grade astrocytomas.
- Multimodal treatment, including aggressive resection and adjuvant radiation, can enhance survival outcomes.
- These findings aid in optimizing treatment strategies for supratentorial low-grade astrocytomas.