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Published on: December 14, 2021
[Pharmacokinetics of beta-asarone in rats]
1First Affiliated Hospital of Guangzhou University of TCM, Guangzhou 510405, China. benzwoo3000@163.com
Aim:
To study the pharmacokinetics of beta-asarone in rats.
Methods:
The concentration of beta-asarone in serum and organs were measured by HPLC after i.g. administration, the pharmacokinetics was analyzed with DAS software regarding the organs as independent system.
Results:
The pharmacokinetics of beta-asarone can be described as first order process of one-compartment model. In the serum, T(1/2), Tpeak and Cmax were 54 min, 12 min and 3.19 mg x L(-1), respectively. The procedure in the organs was similar to that in serum.
Conclusion:
The absorption, distribution and elimination of beta-asarone are very rapid, and it is easy to pass through blood brain barrier. Brain is an important organ of distributing of beta-asarone.
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