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Late-onset multiple sclerosis mimicking brain tumor: a case report
Kazuhisa Iwamoto1, Hidehiro Oka, Satoshi Utsuki
1Department of Neurosurgery, Kitasato University School of Medicine, 1-15-1 Kitasato, Sagamihara, Kanagawa 228-8555, Japan.
Brain Tumor Pathology
|February 11, 2005
Summary
Late-onset multiple sclerosis (MS) can mimic brain tumors in elderly patients, presenting as rapidly progressive single lesions. Early diagnosis and treatment are crucial for symptom improvement and preventing relapse.
Area of Science:
- Neurology
- Neuroimaging
- Pathology
Background:
- Multiple sclerosis (MS) typically affects young adults.
- Late-onset MS is rare and can present atypically.
Observation:
- A 69-year-old woman presented with rapidly progressive left hemiparesis.
- MRI revealed a large, solitary lesion mimicking a brain tumor.
- Stereotactic biopsy confirmed a demyelinating disease, consistent with MS.
Findings:
- The patient responded well to steroid pulse therapy.
- No relapse was observed during over a year of follow-up.
- Histopathology confirmed late-onset multiple sclerosis.
Implications:
- Late-onset MS should be considered in elderly patients with solitary brain lesions.
- Absence of edema or mass effect on MRI may suggest MS over a tumor.
- Prompt diagnosis and treatment can lead to significant symptom improvement and sustained remission.