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D-Amino acid oxidase: structure, catalytic mechanism, and practical application
V I Tishkov1, S V Khoronenkova
1Department of Chemical Enzymology, Faculty of Chemistry, Lomonosov Moscow State University, Moscow 119992, Russia. tishkov@pochta.ru
Biochemistry. Biokhimiia
|February 11, 2005
Summary
D-Amino acid oxidase (DAAO) is a crucial enzyme in metabolism and has applications in producing cephalosporin antibiotics. This review covers DAAO
Area of Science:
- Biochemistry
- Enzymology
- Microbial Metabolism
Background:
- D-Amino acid oxidase (DAAO) is a FAD-dependent enzyme.
- It plays roles in microbial metabolism, nervous system regulation, and aging.
Purpose of the Study:
- To review recent data on DAAO.
- Focus on enzyme localization, physiological role, gene cloning, expression, structure, stability, catalytic mechanism, and applications.
Main Methods:
- Literature review of recent studies on DAAO.
- Synthesis of data on enzyme properties and functions.
Main Results:
- DAAO is vital in various biological processes.
- Yeast-derived DAAO is used in cephalosporin production.
- Recent research has advanced understanding of DAAO's structure and function.
Conclusions:
- DAAO is a versatile enzyme with significant biological and industrial importance.
- Further research continues to uncover its potential applications.