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Basal cell carcinoma with matrical differentiation: a case study with analysis of beta-catenin
Henry D Haskell1, Harley A Haynes, Phillip H McKee
1Department of Pathology, Division of Dermatopathology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.
Abstract:
Matrical differentiation in basal cell carcinoma (BCC) is rare. Only nine cases have been described that showed typical diagnostic features of BCC, in addition to shadow cells indicating hair-matrix differentiation. These cases often present a diagnostic challenge due to confusion with pilomatrixoma or pilomatrix carcinoma. We present a case of BCC with matrical differentiation in a 78-year-old man. Immunohistochemical and molecular methods are used to differentiate this lesion from benign or malignant forms of pilomatrixoma. differentiation: a case study with analysis of beta-catenin.
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