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Related Experiment Videos

Repeated open application test with methyldibromo glutaronitrile, a multicentre study within the EECDRG.

B Gruvberger1, K E Andersen, F M Brandão

  • 1Department of Occupational and Environmental Dermatology, Malmö University Hospital, S-205 02 Malmö, Sweden. birgitta.gruvberger@derm.mas.lu.se

Contact Dermatitis
|February 11, 2005
PubMed
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Lower concentrations of methyldibromo glutaronitrile (MDBGN) in patch testing may miss allergic contact dermatitis cases. Testing with 0.3% and 0.1% MDBGN is insufficient for diagnosing relevant contact allergies.

Area of Science:

  • Dermatology
  • Allergology
  • Toxicology

Background:

  • Methyldibromo glutaronitrile (MDBGN) is a known contact allergen.
  • Allergic contact dermatitis from MDBGN is frequently reported.
  • Optimal diagnostic patch test preparations for MDBGN are needed.

Purpose of the Study:

  • To determine the optimal patch test preparation for methyldibromo glutaronitrile (MDBGN).
  • To evaluate the diagnostic accuracy of different MDBGN concentrations in patch testing.

Main Methods:

  • 51 patients with suspected MDBGN allergy underwent patch testing with MDBGN at 1.0%, 0.5%, 0.3%, and 0.1% in petrolatum.
  • A repeated open application test (ROAT) using moisturizers with and without 0.03% MDBGN was performed on the upper arms for 2 weeks.
  • Patch test reactivity (PTRL) was correlated with ROAT outcomes.

Related Experiment Videos

Main Results:

  • 18 out of 51 patients (35.3%) showed a positive ROAT, exclusively to the MDBGN-containing moisturizer.
  • A significant association was found between patch test reactivity and ROAT results (P < 0.001).
  • Lower MDBGN concentrations (0.3% and 0.1%) in patch tests were found to miss clinically relevant reactions.

Conclusions:

  • Patch testing with methyldibromo glutaronitrile (MDBGN) at 0.3% and 0.1% concentrations is inadequate for diagnosing relevant allergic contact dermatitis.
  • Higher concentrations or alternative testing methods may be necessary for accurate MDBGN allergy diagnosis.