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Simple devices for dispensing [18F]FDG.
Jong O Park1, Hyuk Lee, Young Soon Shin
1Department of Nuclear Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, 50 Ilwon-dong, Kangnam-ku, Seoul 135-710, Republic of Korea.
Summary
Automated synthesis of high-dose Fluorodeoxyglucose (18F) requires a specialized dispenser. This study introduces simple devices for efficient vial-to-vial and vial-to-syringe dispensing, reducing radiation exposure.
Area of Science:
- Nuclear Medicine
- Radiopharmacy
- Medical Imaging
Background:
- High-dose (18F)Fluorodeoxyglucose ((18F)FDG) is routinely prepared using automated synthesizers for positron emission tomography (PET) imaging.
- Current dispensing methods for (18F)FDG pose radiation exposure risks to operators.
- A need exists for a system capable of both vial-to-vial and vial-to-syringe dispensing of (18F)FDG.
Purpose of the Study:
- To develop and describe simple devices for automated dispensing of (18F)FDG.
- To enable both vial-to-vial and vial-to-syringe dispensing within a single system.
- To reduce radiation exposure for nuclear medicine technologists handling (18F)FDG.
Main Methods:
- Design and construction of novel dispensing devices for (18F)FDG.
- Integration of vial-to-vial and vial-to-syringe dispensing capabilities.
- Testing of devices for dose accuracy and reliability in a radiopharmacy setting.
Main Results:
- Successful development of simple devices for (18F)FDG dispensing.
- Demonstrated capability for both vial-to-vial and vial-to-syringe transfer.
- Potential for significant reduction in operator radiation dose.
Conclusions:
- The described devices offer a practical solution for automated (18F)FDG dispensing.
- These innovations address the lack of commercial systems for combined vial-to-vial and vial-to-syringe transfer.
- Implementation can enhance safety and efficiency in nuclear medicine practices.