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From drug to protein: using yeast genetics for high-throughput target discovery
Christopher D Armour1, Pek Yee Lum
1Rosetta Inpharmatics LLC, Merck & Co., Inc., 401 Terry Avenue North, Seattle, Washington 98109, USA. christopher_armour@merck.com
Current Opinion in Chemical Biology
|February 11, 2005
Abstract:
The budding yeast Saccharomyces cerevisiae has long been an effective eukaryotic model system for understanding basic cellular processes. The genetic tractability and ease of manipulation in the laboratory make yeast well suited for large-scale chemical and genetic screens. Several recent studies describing the use of yeast genetics for high-throughput drug target identification are discussed in this review.