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[Free radicals in clinical biology. Origin, pathogenic effect and defense mechanisms]
1Laboratoire de Biochimie, Hôpital Corentin Celton, Issy-Les-Moulineaux, France.
Pathologie-Biologie
|January 1, 1992
Abstract:
Free radicals are chemical species with an unpaired electron on their outer orbit. This review discusses the various endogenous and exogenous sources of free radicals; toxicity of free radicals, especially for DNA and cell membranes; a number of pathophysiologic states related to overproduction of free radicals; the natural protective systems--involving enzymes or scavengers--which prevent free radical-induced cell injury, and therapeutic trials of antioxidants for improving protection against free radicals in a number of conditions.