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Maternal and infant characteristics associated with perinatal arterial stroke in the infant

Janet Lee1, Lisa A Croen, Kendall H Backstrand

  • 1Department of Neurology, University of California, San Francisco, CA 94117, USA.

JAMA
|February 11, 2005
PubMed

Insights

Perinatal arterial ischemic stroke (PAS) is linked to maternal factors like infertility and preeclampsia. Identifying these risk factors can help prevent infant brain injury and cerebral palsy.

Area of Science:

  • Neurology
  • Obstetrics
  • Pediatrics

Background:

  • Perinatal arterial ischemic stroke (PAS) is a significant cause of hemiplegic cerebral palsy.
  • Risk factors contributing to PAS remain incompletely understood.

Purpose of the Study:

  • To identify maternal and infant characteristics associated with the occurrence of PAS.
  • To elucidate potential risk factors for perinatal stroke.

Main Methods:

  • A case-control study was conducted within a large birth cohort (199,176 infants).
  • 40 confirmed PAS cases were compared with three randomly selected controls per case.
  • Maternal and infant complications were analyzed for association with PAS.

Main Results:

  • PAS prevalence was 20 per 100,000 live births, with 85% of affected infants born at term.
  • Factors like primiparity, fetal heart rate abnormalities, emergency cesarean delivery, chorioamnionitis, prolonged rupture of membranes, and preeclampsia were more common in PAS cases.
  • Independent risk factors identified through multivariate analysis included infertility, preeclampsia, prolonged rupture of membranes, and chorioamnionitis.

Conclusions:

  • Perinatal arterial ischemic stroke is associated with several distinct maternal risk factors.
  • Further research is warranted to understand how these maternal complications influence placental and fetal health, potentially leading to perinatal stroke.
Abstract

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