Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Methotrexate and oral ulceration.

G M J Deeming1, J Collingwood, M N Pemberton

  • 1Unit of Oral Medicine, University Dental Hospital of Manchester, Higher Cambridge Street, Manchester M15 6FH.

British Dental Journal
|February 11, 2005
PubMed
Summary

Dentists may see oral side effects from methotrexate, a drug used for cancer and inflammatory conditions. Proper folic acid supplementation and correct dosing are crucial to prevent oral ulceration in patients.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Wrong tooth extraction: further analysis of "never event" data.

The British journal of oral & maxillofacial surgery·2019
Same author

Trends in referral format and dental notation used in primary care referrals to dental specialists.

British dental journal·2018
Same author

Oral cancer and tobacco: developments in harm reduction.

British dental journal·2018
Same author

Patient safety: Never say never.

British dental journal·2018
Same author

Morbidity and mortality associated with the interaction of miconazole oral gel and warfarin.

British dental journal·2018
Same author

Oral Medicine for undergraduate dental students in the United Kingdom and Ireland-A curriculum.

European journal of dental education : official journal of the Association for Dental Education in Europe·2018

Area of Science:

  • Oncology
  • Rheumatology
  • Dermatology

Background:

  • Methotrexate is a cornerstone in treating neoplastic diseases.
  • Low-dose, once-weekly methotrexate is increasingly used for psoriasis and rheumatoid arthritis.
  • Dental practitioners will likely encounter patients on methotrexate therapy.

Observation:

  • Oral ulceration is a potential side effect of methotrexate.
  • This can result from inadequate folic acid supplementation.
  • Confusion regarding the once-weekly dosing regimen may lead to overdosage.

Findings:

  • Clinical trials confirm methotrexate's efficacy in treating psoriasis and rheumatoid arthritis.
  • Oral side effects, such as ulceration, have presented initially in dental settings.
  • Key drug interactions relevant to dental treatment are identified.

Implications:

  • Awareness of methotrexate's oral side effects is essential for dentists.
  • Ensuring adequate folic acid intake is vital for patients on methotrexate.
  • Clear patient education on methotrexate dosing is necessary to prevent adverse events.

Related Experiment Videos