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Related Experiment Videos

Hyperbaric oxygen and radiotherapy.

Ramona Mayer1, Martin R Hamilton-Farrell, Adrian J van der Kleij

  • 1Department of Radiation Oncology, Medical University of Graz, Austria.

Strahlentherapie Und Onkologie : Organ Der Deutschen Rontgengesellschaft ... [Et Al]
|February 11, 2005
PubMed
Summary

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Hyperbaric oxygen (HBO) therapy enhances radiation oncology by promoting new vessel growth and sensitizing tumors to irradiation. Clinical studies explore its use in head and neck cancers, glioblastoma, and pelvic region treatments.

Area of Science:

  • Oncology
  • Hyperbaric Medicine

Background:

  • Hyperbaric oxygen (HBO) therapy involves inhaling 100% oxygen at elevated pressures (≥1.5 ATA).
  • HBO delivers oxygen dissolved in plasma, bypassing hemoglobin to reach tissues.
  • It promotes neovascularization in hypoxic areas, aiding wound healing and radiation-injured tissue recovery.
  • HBO can sensitize tumors to irradiation by increasing intratumoral oxygen levels.

Purpose of the Study:

  • To provide an overview of HBO therapy in radiation oncology.
  • To present findings from ongoing European clinical studies within the COST B14 action framework.
  • To encourage recruitment for prospective studies in HBO and radiation oncology.

Main Methods:

  • A network of European hyperbaric facilities is involved.

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  • Prospective study protocols are being developed and implemented.
  • Specific clinical studies include reirradiation of head and neck cancers, glioblastoma radiosensitization, osseointegration, and pelvic late sequelae treatment.

    • Main Results:

    • Randomized clinical studies investigated HBO for recurrent head and neck squamous cell carcinoma and glioblastoma multiforme radiosensitization.
    • Adjunctive HBO was studied for preventing implant failures and treating pelvic radiation sequelae.
    • Radiosensitization protocols allowed a 10-20 minute interval between HBO and subsequent irradiation.

    Conclusions:

    • Recruitment of centers and patients is crucial for advancing research.
    • Detailed information on ongoing studies and participation is available at www.oxynet.org.