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Evaluating the Effectiveness of Cancer Drug Sensitization In Vitro and In Vivo
09:19

Evaluating the Effectiveness of Cancer Drug Sensitization In Vitro and In Vivo

Published on: February 6, 2015

Design and analysis of in vitro experiments for combination chemotherapy

T Le Chap1, Patricia M Grambsch

  • 1School of Public Health, University of Minnesota, Minneapolis, Minnesota 55455, USA. chap@biostat.umn.edu

Journal of Biopharmaceutical Statistics
|February 11, 2005
PubMed

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Combination Therapies and Personalized Medicine02:50

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Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...