Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Pulse pressure as a risk factor.

Stanley S Franklin1

  • 1UCI Heart Disease Prevention Program, C240 Medical Sciences, University of California, Irvine, California 92697, USA. ssfranklinmd@earthlink.net

Clinical and Experimental Hypertension (New York, N.Y. : 1993)
|February 11, 2005
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Cardiovascular Events and Mortality in White Coat Hypertension.

Annals of internal medicine·2019
Same author

Superiority of Out-of-Office Blood Pressure for Predicting Hypertensive Heart Disease in Non-Hispanic Black Adults.

Hypertension (Dallas, Tex. : 1979)·2019
Same author

Reply.

Journal of hypertension·2017
Same author

Cardiovascular Risk Associated With White-Coat Hypertension: Con Side of the Argument.

Hypertension (Dallas, Tex. : 1979)·2017
Same author

Expertise: no longer a sine qua non for guideline authors?

Journal of hypertension·2017
Same author

Expertise: No Longer a Sine Qua Non for Guideline Authors?

Hypertension (Dallas, Tex. : 1979)·2017
Same journal

Adiponectin improves the aortic dissection by inhibiting inflammatory cell infiltration and macrophage pyroptosis.

Clinical and experimental hypertension (New York, N.Y. : 1993)·2026
Same journal

Electroacupuncture for essential hypertension: Mechanistic insights, current clinical evidence, and translational challenges.

Clinical and experimental hypertension (New York, N.Y. : 1993)·2026
Same journal

Association of intracranial atherosclerotic stenosis with 1-year cognitive impairment after acute ischemic stroke or transient ischemic attack: a nationwide prospective cohort study.

Clinical and experimental hypertension (New York, N.Y. : 1993)·2026
Same journal

Frailty as a mediator of the association between hyperuricemia and stroke risk: A prospective cohort study.

Clinical and experimental hypertension (New York, N.Y. : 1993)·2026
Same journal

Synergistic impact of nondipper heart rate and blood pressure on left ventricular hypertrophy in essential hypertension.

Clinical and experimental hypertension (New York, N.Y. : 1993)·2026
Same journal

From clinic to home monitoring: Diagnostic strategies and evidence landscape of white-coat uncontrolled hypertension.

Clinical and experimental hypertension (New York, N.Y. : 1993)·2026
See all related articles

Pulse pressure (PP) may predict cardiovascular risk and antihypertensive therapy benefits. However, systolic blood pressure (SBP) remains the primary target for public health recommendations due to its overall predictive value.

Area of Science:

  • Cardiovascular Medicine
  • Hypertension Research
  • Arterial Stiffness Epidemiology

Background:

  • Increased pulse pressure (PP) after age 60 is linked to central artery stiffness, a known cardiovascular disease risk factor.
  • The comparative predictive value of PP versus systolic blood pressure (SBP) and mean arterial pressure (MAP) for cardiovascular risk remains debated.

Purpose of the Study:

  • To review evidence questioning the Prospective Studies Collaboration (PSC) findings that MAP is superior to PP in predicting cardiovascular risk.
  • To evaluate the utility of PP in predicting cardiovascular risk and response to antihypertensive therapy.

Main Methods:

  • Review of existing scientific literature and evidence, including the role of pulse wave reflection.
  • Analysis of the advantages and disadvantages of using PP as a cardiovascular risk predictor.

Related Experiment Videos

Main Results:

  • Evidence suggests PP may be a useful predictor of cardiovascular risk, particularly with normal or compromised cardiac function.
  • PP may also predict the benefits of antihypertensive drug therapy.
  • Contradictory findings exist, with some studies, like the PSC, favoring MAP over PP for risk prediction.

Conclusions:

  • Public health recommendations should continue to prioritize SBP as the primary target for defining cardiovascular risk and guiding therapy.
  • While PP has potential utility, its role requires further clarification in the context of established risk factors like SBP.