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Updated: Jul 26, 2026
10:08
The Evoked Potential Operant Conditioning System (EPOCS): A Research Tool and an Emerging Therapy for Chronic Neuromuscular Disorders
Published on: August 25, 2022
[The opsoclonus-myoclonus syndrome]
C de Brabander1, J I Hoff, C C Tijssen
1Afd. Neurologie, Leids Universitair Medisch Centrum, Postbus 9600, 2300 RC Leiden. c.de_brabander@lumc.nl
Nederlands Tijdschrift Voor Geneeskunde
|February 11, 2005
Summary
Opsoclonus-myoclonus syndrome (OMS) is a rare neurological disorder characterized by rapid eye movements and muscle jerks. Causes include infections, malignancy, or unknown factors, with screening for cancer recommended.
Area of Science:
- Neurology
- Immunology
Background:
- Opsoclonus-myoclonus syndrome (OMS) is a rare neurological disorder.
- Characterized by opsoclonus (rapid, involuntary saccadic eye movements) and myoclonus (sudden, involuntary muscle contractions).
Observation:
- Nine patients (2 male, 7 female, aged 34-65) diagnosed with OMS.
- Identified causes included post-infectious (2), malignancy (3), medication-related (1), and unknown (3).
Findings:
- OMS is associated with infections, malignancies, intoxications, and metabolic disorders.
- In 50% of cases, the etiology remains unidentified.
- Evidence suggests brainstem and cerebellar pathway dysfunction, often involving autoimmune processes.
Implications:
- Screening for occult malignancy is crucial once OMS is diagnosed.
- Prognosis for idiopathic and post-infectious OMS is generally favorable.
- Treatment primarily focuses on supportive care.
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