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Updated: Aug 19, 2026
Lateral Fluid Percussion: Model of Traumatic Brain Injury in Mice
Published on: August 22, 2011
[Expression of PDGF-B after fluid percussion brain injury in rats]
Lei-bo Li1, Xiao-gang Chen, Min Liu
1Department of Forensic Pathology, West China School of Preclinical and Forensic Medicine, Sichuan University, Chengdu 610041, China.
Objective:
To elucidate the changes of PDGF-B chain in the brain injured by fluid percussion.
Methods:
The expression of PDGF-B protein was studied by immunohistochemistry and the results were assessed by image analysis system.
Results:
Enhanced expression of PDGF-B protein induced by fluid percussion injury was seen at 1 h, and its marked up-regulation was noted at 4-7 days, and then the expression became decreased but it remained above the control levels till 14 days after injury.
Conclusion:
Fluid percussion brain injury induced expression of PDGF-B. The regular change pattern of PDGF-B level in time course seems to be of value in estimating the age of brain injury.
