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[The preparation of PELGE-NP and a study of the factors affecting their diameter]
You-rong Duan1, Zhi-rong Zhang, Yong-gang Tang
1West China School of Pharmacy, Sichuan University, Chengdu 610041, China.
Objective:
To prepare Poly(ethylene glycol)-poly(lacticacid-co-glycolicacid)-poly(ethylene-glycol) nanoparticles (PELGE-NP) and investigate the factors affecting their diameter.
Methods:
PELGE were synthesized by ring-opening polymerization, PELGE nanoparticles (PELGE-NP) were prepared by using the emulsion-solvent evaporation technique (O/W). Orthogonal design was applied to optimize the preparation technology on the basis of the single factor evaluation.
Results:
The optimal conditions for preparing nanoparticles included the PELGE at concentration of 10 mg/ml, the ratio of acetone/DCM at 2/3, the F68 at concentration of 3%, and the volume ratio of O/W at 1/8 (V/V).
Conclusion:
The prepared PELGE nanoparticles are spherical and discrete particles without aggregation; they are smooth in surface morphology, and their diameters range from 60 nm to 100 nm.
