Related Experiment Videos
Effects of inhaled corticosteroids on bone
K J Mortimer1, T W Harrison, A E Tattersfield
1Division of Respiratory Medicine, Nottingham University City Hospital, Nottingham, England. Kevin.Mortimer@nottingham.ac.uk
Summary
Inhaled corticosteroids can reduce bone mineral density and increase fracture risk, particularly at higher doses. These systemic effects on bone health have significant public health implications for users.
Area of Science:
- Pharmacology
- Bone Metabolism
- Public Health
Background:
- Inhaled corticosteroids (ICS) are widely prescribed for respiratory conditions.
- Systemic absorption of ICS can lead to off-target effects.
- Bone health is a critical concern for long-term medication users.
Purpose of the Study:
- To review the effects of inhaled corticosteroids on bone health.
- To discuss the public health implications of these bone-related effects.
Main Methods:
- Comprehensive literature search of MEDLINE and EMBASE databases (1966-2004).
- Keywords included specific ICS names and bone-related outcomes (fracture, osteoporosis, growth).
- Selection of large, duration-appropriate studies addressing potential confounders.
Main Results:
- ICS are systemically absorbed, posing a risk to bone.
- Dose-dependent reductions in bone mineral density were observed.
- Increased fracture risk and short-term growth velocity reduction in children were noted.
Conclusions:
- Given the prevalence of ICS use and osteoporotic fractures, findings have significant public health implications.
- Strategies to mitigate systemic ICS effects on bone are necessary.
- Further research into safer delivery or alternative treatments may be warranted.