Related Experiment Video
Updated: Aug 19, 2026

Differentiated Mouse Adipocytes in Primary Culture: A Model of Insulin Resistance
Published on: February 17, 2023
[PPARs: the role in glucose and lipid homeostasis, insulin resistance and atherosclerosis]
1Ustav fyziologie, Lékarská fakulta Univerzity Palackého v Olomouci.
Abstract:
This review deals with general mechanisms of peroxisome proliferator-activated receptors (PPARs) functions, describes the mode of action of various PPAR subtypes in different tissues and their participation in transcription of genes governing lipid and glucose homeostasis. The hypothetic role of free fatty acids in mediating metabolic effects of PPARs, their role in insulin resistance and genetic studies highlighting the ligand-independent activation and post-translational modification of PPARgamma are disscussed in details. A possible role for PPARs in atherosclerosis, especially in connection with macrophage function in this process, is also explained.
Related Concept Videos
Insulin: The Receptor and Signaling Pathways
Glucose Homeostasis: Regulation of Blood Glucose
During fasting, when blood glucose levels are low, the pancreas secretes glucagon. it...
Type II Diabetes II: Pathophysiology
Glucose Homeostasis: Pancreatic Islets and Insulin Secretion
Insulin and C-peptide are co-secreted in...
Hormones Regulating Blood Glucose
In addition to accelerating glucose uptake and utilization, insulin has...
Cell Specific Gene Expression
