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Calcinosis circumscripta in the dog: a retrospective pathological study.
A K Tafti1, P Hanna, A C Bourque
1Department of Pathology, School of Veterinary Medicine, Shiraz University, P.O. Box 71345-1731, Shiraz, Iran.
Summary
Calcinosis circumscripta, a soft tissue mineralization, is uncommon in dogs, often affecting young, large breeds like German Shepherds. This study details 77 cases, noting common locations and microscopic findings, including a rare intestinal case.
Area of Science:
- Veterinary Pathology
- Canine Medicine
- Soft Tissue Mineralization
Background:
- Calcinosis circumscripta involves ectopic deposition of calcium salts in soft tissues.
- It can be idiopathic, dystrophic, metastatic, or iatrogenic.
- This study focuses on canine cases, a less common presentation.
Purpose of the Study:
- To retrospectively analyze 77 canine cases of calcinosis circumscripta.
- To characterize the signalment, lesion characteristics, and microscopic findings.
- To report the first case of idiopathic intestinal calcinosis circumscripta in dogs.
Main Methods:
- Retrospective review of 77 canine medical records and histopathology reports.
- Analysis of signalment (age, breed), lesion location, size, and number.
- Histopathological examination of tissue samples.
Main Results:
- Most cases (88%) occurred in dogs under 4 years old, with German Shepherds, Rottweilers, and Labrador Retrievers being common breeds.
- Lesions were typically solitary (82%), ranged from 2 mm to 13 cm, and most frequently occurred on hind feet (50%) and tongue (23%).
- Histopathology revealed amorphous to granular basophilic material with or without granulomatous reaction and fibrous connective tissue; one dog had jejunal lesions.
Conclusions:
- Calcinosis circumscripta in dogs predominantly affects young, large breed animals.
- Hind feet and tongue are common sites for lesions.
- Idiopathic intestinal calcinosis circumscripta is a newly identified, rare manifestation in dogs.