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Updated: Aug 19, 2026
A Large Animal Model for Acute Kidney Injury by Temporary Bilateral Renal Artery Occlusion
Published on: February 2, 2021
Effect of shock wave reapplication on urinary N-acetyl-beta-glucosaminidase in canine kidney
Marco A Q R Fortes1, Adagmar Andriolo, Valdemar Ortiz
1Division of Urology, Paulista School of Medicine, Federal University of São Paulo, UNIFESP, São Paulo, SP, Brazil. fortesmarco@hotmail.com
Objective:
Renal tubular damage can be assessed with the aid of urinary dosing of N-acetyl-beta-glucosaminidase (NAG) and it is possible to demonstrate a significant correlation between shock wave and damage to renal parenchyma. The objective of this study was to assess the effect of shock wave reapplication over urinary NAG in canine kidney.
Materials And Methods:
The authors submitted 10 crossbred dogs to 2 applications of 2000 shock waves in a 24-hour interval in order to assess urinary NAG values after 12, 24, 36 and 48 hours.
Results:
Twelve hours following the first shockwave application there was an increase in NAG of 6.47 +/- 5.44 u/g creatinine (p < 0.05). Twelve hours and 24 h following the second application there was no increase in the urinary enzyme, -2.56 +/- -7.36 u/g creatinine and 2.89 +/- -7.27 u/g creatinine, respectively (p > 0.05).
Conclusion:
Shock wave reapplication with a 24-hour interval did not cause any increase in urinary NAG.
