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Related Experiment Videos

Depression-executive dysfunction syndrome in stroke patients.

Risto Vataja1, Tarja Pohjasvaara, Riitta Mäntylä

  • 1Memory Research Unit, Department of Neurology, Helsinki University Central Hospital, P.O. BOX 300, FIN-00029 HUS, Finland.

The American Journal of Geriatric Psychiatry : Official Journal of the American Association for Geriatric Psychiatry
|February 11, 2005
PubMed
Summary

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Poststroke depression with executive dysfunction (DES) is linked to frontal-subcortical brain infarcts. This condition is associated with poorer outcomes and daily functioning.

Area of Science:

  • Neurology
  • Psychiatry
  • Neuropsychology

Background:

  • Executive dysfunction may underlie geriatric and vascular depression.
  • This depression-dysexecutive syndrome (DES) could stem from frontal-subcortical circuit issues.

Purpose of the Study:

  • To investigate the link between depression, executive dysfunction, and frontal-subcortical circuit pathology in poststroke patients.

Main Methods:

  • Cross-sectional cohort study of 158 ischemic stroke patients.
  • Neurological, psychiatric, and neuropsychological assessments at 3 months post-stroke.
  • MRI to evaluate brain infarcts, white-matter changes, and atrophy.

Main Results:

  • Patients with DES (n=21) showed more frontal-subcortical infarcts than those without DES (n=137) or depression without executive dysfunction (n=41).

Related Experiment Videos

  • DES patients exhibited more severe depressive symptoms and worse psychosocial functioning.
  • Impaired coping in complex daily activities was noted in DES patients.

    • Conclusions:

    • Depression-dysexecutive syndrome (DES) is a valid clinical concept.
    • DES may identify a distinct subgroup of poststroke patients with frontal-subcortical pathology.
    • This subgroup may have unique prognostic and therapeutic considerations.