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Long-term mortality after preeclampsia.

Edmund F Funai1, Yechiel Friedlander, Ora Paltiel

  • 1Section of Maternal-Fetal Medicine, Department of Obstetrics & Gynecology, Yale University School of Medicine, New Haven, Connecticut 06520-8063, USA. edmund.funai@yale.edu

Epidemiology (Cambridge, Mass.)
|February 11, 2005
PubMed
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Preeclampsia significantly increases long-term mortality risk, primarily from cardiovascular disease. This risk persists even in women with normal blood pressure after pregnancy, highlighting the need for ongoing monitoring.

Area of Science:

  • Obstetrics and Gynecology
  • Cardiovascular Epidemiology
  • Reproductive Health

Background:

  • Preeclampsia is often mistakenly believed to have no long-term health consequences.
  • This study addresses the underestimation of preeclampsia's association with future mortality.

Purpose of the Study:

  • To investigate the long-term mortality risk in women diagnosed with preeclampsia.
  • To focus on the mortality risk in women who subsequently had normal blood pressure.

Main Methods:

  • A cohort study followed 37,061 women for 24-36 years, including 1,070 with preeclampsia.
  • Cox proportional hazard models were used to assess mortality risk, adjusting for multiple covariates.

Main Results:

  • Women with preeclampsia had a 2.1-fold increased relative risk of death (95% CI = 1.8-2.5).

Related Experiment Videos

  • Cardiovascular disease was the leading cause of increased mortality.
  • Excess mortality risk became apparent after 20 years in women with preeclampsia followed by normotensive pregnancies.

    • Conclusions:

    • Preeclampsia is a significant risk marker for future cardiovascular disease mortality.
    • Normal blood pressure post-preeclampsia should not deter the assessment of other cardiovascular risk factors or preventive strategies.