Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Gastroduodenal motility.

Davendra Ramkumar1, Konrad S Schulze

  • 1University of Iowa HealthCare and VAMC, Iowa City, Iowa, USA. davendra_ramkumar@uiowa.edu

Current Opinion in Gastroenterology
|February 11, 2005
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Food for thought: Making the case for food produced via regenerative agriculture in the battle against non-communicable chronic diseases (NCDs).

One health (Amsterdam, Netherlands)·2024
Same author

Endoscopic grading of myochosis and its association with colonic obstructive symptoms.

Digestive endoscopy : official journal of the Japan Gastroenterological Endoscopy Society·2017
Same author

Pill Properties that Cause Dysphagia and Treatment Failure.

Current therapeutic research, clinical and experimental·2015
Same author

Isolation of Primary Human Colon Tumor Cells from Surgical Tissues and Culturing Them Directly on Soft Elastic Substrates for Traction Cytometry.

Journal of visualized experiments : JoVE·2015
Same author

Comments on nonsteroidal anti-inflammatory drug enteropathy.

Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association·2009
Same author

Investigation of fundo-antral reflex in human beings.

World journal of gastroenterology·2006

Understanding upper gastrointestinal motility is key for digestion and satiety. New imaging techniques and targeted therapies show promise for treating gastroparesis, a condition affecting stomach and duodenal function.

Area of Science:

  • Gastroenterology
  • Neurogastroenterology
  • Digestive Physiology

Background:

  • Upper gastrointestinal motility, governed by neuromuscular functions, drives digestion and influences satiety and dyspepsia.
  • Neuroendocrine factors play a crucial role in regulating these functions.

Purpose of the Study:

  • To review neuroendocrine control of upper gastrointestinal motility.
  • To discuss noninvasive techniques for evaluating gastroduodenal motility.
  • To examine the pathophysiology and treatment of gastroparesis.

Main Methods:

  • Review of current literature on neuroendocrine factors, motility assessment techniques, and gastroparesis.
  • Discussion of noninvasive imaging modalities like MRI for evaluating gastric function.
  • Analysis of emerging therapeutic strategies for gastroparesis.

Related Experiment Videos

Main Results:

  • Nutrient sensing in the duodenum triggers feedback inhibition of gastric emptying via cholecystokinin (CCK) and serotonin (5-HT).
  • Tumor necrosis factor-alpha (TNF-α) mediates gastric inhibition through the dorsal vagal complex.
  • Magnetic resonance imaging (MRI) offers a noninvasive method for assessing gastric accommodation and contractions, comparing favorably with the barostat.
  • Gastroparesis is linked to end-stage liver disease, with portal hypertension contributing to gastric dysfunction.
  • Clonidine, sildenafil, and intrapyloric botulinum toxin show potential in treating gastroparesis.

Conclusions:

  • Future drug development may target specific receptors (5-HT3, CCK, TNF-α).
  • Spatiotemporal mapping using advanced imaging (ultrasound, CT, MRI) can enhance diagnostic capabilities.
  • Improving gastric accommodation may be more beneficial for gastroparesis symptom relief than solely enhancing gastric emptying.