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Microscopic colitis.

John R Stroehlein1

  • 1M.D. Anderson Cancer Center, Houston, Texas 77030-4009, USA. jrstroeh@mdanderson.org

Current Opinion in Gastroenterology
|February 11, 2005
PubMed
Summary

Microscopic colitis, a cause of chronic diarrhea, is diagnosed via biopsy. Budesonide is a highly effective treatment, offering superior clinical and histologic improvement compared to other options.

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Area of Science:

  • Gastroenterology
  • Internal Medicine

Background:

  • Microscopic colitis is an underrecognized cause of chronic diarrhea.
  • It predominantly affects middle-aged to elderly women and can be linked to medications (NSAIDs), autoimmune conditions, and sprue.

Purpose of the Study:

  • To review the diagnosis, treatment, and prognosis of microscopic colitis.
  • To highlight budesonide as a primary therapeutic option.

Main Methods:

  • Review of existing literature on microscopic colitis.
  • Analysis of treatment efficacy based on randomized trials.

Main Results:

  • Budesonide demonstrates superior efficacy in achieving clinical and histologic remission compared to other treatments.
  • Symptomatic treatments like cholestyramine and antidiarrheals offer relief.
  • Immune modulators and surgery are reserved for refractory cases.

Conclusions:

  • Microscopic colitis requires diagnosis via biopsy.
  • Budesonide is the most effective pharmacologic treatment.
  • Surgical options are effective for refractory disease and do not increase cancer risk.

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