Related Experiment Video

Updated: Aug 19, 2026

Cutoff Value of Phase Angle by Bioelectrical Impedance Analysis at Admission as a Prognostic Factor in Patients with Acute Heart Failure
05:16

Cutoff Value of Phase Angle by Bioelectrical Impedance Analysis at Admission as a Prognostic Factor in Patients with Acute Heart Failure

Published on: June 10, 2025

Prognostic value of elevated circulating heart-type fatty acid binding protein in patients with congestive heart

Takanori Arimoto1, Yasuchika Takeishi, Ryoko Shiga

  • 1First Department of Internal Medicine, Yamagata University School of Medicine, Yamagata, Japan.

Journal of Cardiac Failure
|February 11, 2005
PubMed

Insights

Elevated heart-type fatty acid binding protein (H-FABP) indicates ongoing heart damage and predicts future cardiac events in patients with congestive heart failure, highlighting its clinical significance.

Area of Science:

  • Cardiology
  • Biomarker Research
  • Heart Failure Management

Background:

  • Heart-type fatty acid binding protein (H-FABP) is a biomarker released upon myocardial injury.
  • H-FABP is a novel marker for diagnosing acute myocardial infarction.
  • The clinical significance of H-FABP in congestive heart failure (CHF) requires examination.

Purpose of the Study:

  • To investigate the clinical significance of elevated serum H-FABP levels in patients diagnosed with CHF.
  • To determine if H-FABP levels correlate with disease severity and prognosis in CHF patients.

Main Methods:

  • Serum H-FABP levels were measured in 179 CHF patients and 20 healthy controls using ELISA.
  • Patients were followed for a mean of 20 months for cardiac death and rehospitalization due to heart failure.
  • Cox multivariate proportional hazard analysis was employed to identify independent predictors of cardiac events.

Main Results:

  • Serum H-FABP levels were significantly higher in CHF patients compared to controls (5.7 vs. 2.7 ng/mL, P < .01).
  • H-FABP levels increased with advancing NYHA class (P < .01).
  • Patients with elevated H-FABP had a markedly higher cardiac event rate (43% vs. 7%, P < .0001) and H-FABP was an independent predictor of cardiac events (P < .01).

Conclusions:

  • Elevated serum H-FABP levels signify latent and ongoing cardiomyocyte damage in CHF patients.
  • Increased H-FABP identifies CHF patients at high risk for future cardiac events.
  • H-FABP serves as a valuable prognostic marker in congestive heart failure management.
Abstract

More Related Videos

Coronary Progenitor Cells and Soluble Biomarkers in Cardiovascular Prognosis after Coronary Angioplasty10:03

Coronary Progenitor Cells and Soluble Biomarkers in Cardiovascular Prognosis after Coronary Angioplasty

Published on: January 28, 2020

Related Concept Videos

Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers01:19

Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers

Cardiac biomarkers are critical in diagnosing, prognosing, and managing cardiovascular diseases. Routine measurement of specific biomarkers such as B-type natriuretic peptide (BNP), C-reactive protein (CRP), and homocysteine (Hcy) is common practice in clinical settings to evaluate heart function and predict cardiovascular events.
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
Heart Failure IV: Classification and Diagnostic Evaluation01:30

Heart Failure IV: Classification and Diagnostic Evaluation

Heart failure can be classified in various ways, with the most common classifications based on physical activity limitations, disease progression, severity, and treatment strategies.The Functional Classification of Heart Failure divides patients into four categories based on physical activity limitation due to symptom burden.Class I: Patients in this class have cardiac disease but no physical activity limitations. Ordinary activities like walking, climbing stairs, or routine tasks do not cause...
Pathophysiology of Heart Failure01:17

Pathophysiology of Heart Failure

Heart failure (HF) is a progressive syndrome involving ventricles that leads to inadequate cardiac output. It can be classified based on location and output or ejection fraction. Ejection fraction (EF) is an essential measurement in the diagnosis and surveillance of HF. Reduced EF corresponds to systolic heart failure (HFrEF). However, HF with preserved ejection fraction (HFpEF) is becoming increasingly prevalent. Also known as diastolic HF, this form of HF is related to aging. The...
Blood Studies for Cardiovascular System I: Cardiac Biomarkers01:20

Blood Studies for Cardiovascular System I: Cardiac Biomarkers

Cardiac biomarkers are enzymes, proteins, and hormones released into the blood when cardiac cells are injured. They are powerful tools for triaging.
The essential diagnostic tools for detecting myocardial necrosis and monitoring individuals suspected of having acute coronary syndrome (ACS) include:
Troponins
Troponins, particularly cardiac troponins I and T, are the most precise and sensitive markers of myocardial injury. They are detectable within 4-6 hours of myocardial injury and remain...
Heart Failure II: Pathophysiology01:29

Heart Failure II: Pathophysiology

Systolic Heart Failure and Compensatory MechanismsSystolic heart failure (also termed HFrEF, Heart Failure with Reduced Ejection Fraction) is the most prevalent type of heart filure. It results in a decreased volume of blood being pumped from the ventricle. The aortic arch and carotid sinuses have baroreceptors that detect reduced blood pressure, triggering the sympathetic nervous system (SNS) to release epinephrine and norepinephrine. Initially, this response aims to boost heart rate and...
Heart Failure VII: Nursing Interventions01:30

Heart Failure VII: Nursing Interventions

The first step in nursing management of a patient with heart failure involves thoroughly assessing the patient's medical history.Subjective Data: Obtain the patient's medical history of coronary artery disease, hypertension, myocardial infarction, and symptoms like dyspnea, orthopnea, and paroxysmal nocturnal dyspnea.Objective Data: Conduct a physical examination to identify findings such as jugular vein distention, pulmonary crackles, tachycardia, murmurs, peripheral edema, and vital signs,...