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Related Experiment Videos

Thin cylindrical diffusers in multimode Ge-doped silica fibers.

Lothar Lilge1, Leonid Vesselov, William Whittington

  • 1University Health Network, 610 University Avenue, Toronto, Ontario, Canada, M5G 2M9. llilge@uhnres.utoronto.ca

Lasers in Surgery and Medicine
|February 11, 2005
PubMed
Summary

A novel fiber diffuser for photodynamic therapy (PDT) was developed with a 250-micrometer diameter and over 5 cm length. This advancement expands PDT applications by overcoming limitations of traditional diffusers.

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Area of Science:

  • Biomedical Engineering
  • Optical Physics
  • Photodynamic Therapy

Background:

  • Cylindrical fiber diffusers are standard in photodynamic therapy (PDT).
  • Current diffusers have limitations in outer diameter and length, restricting their clinical applications.
  • A need exists for more versatile fiber diffusers in PDT.

Purpose of the Study:

  • To develop a novel fiber diffuser with a reduced outer diameter (250 micrometers) and extended active length (>5 cm).
  • To characterize the photometric properties of the new diffuser.
  • To demonstrate customizability of light emission profiles for enhanced PDT treatment.

Main Methods:

  • Development of diffusers using photosensitive quartz optical fibers (140 micrometers cladding diameter).

Related Experiment Videos

  • Fabrication involved a structured beam from an excimer laser.
  • Comprehensive photometric characterization, including longitudinal, polar, and azimuth radiance emission diagrams.

    • Main Results:

    • Achieved homogenous longitudinal radiance emission within +/-10%.
    • Demonstrated capability for custom longitudinal emission profiles.
    • Polar and azimuth radiance variations were within +/-15% of an ideal Lambertian emitter.
    • Reduced light leakage at the fiber's distal end to 2%.
    • Minimal bending radius of approximately 5 mm achieved after recoating.

    Conclusions:

    • The developed fiber diffuser offers improved uniformity and customizability for PDT applications.
    • Potential for enhanced polar uniformity through recoating.
    • The diffuser exhibits favorable mechanical properties (bending radius) and minimal light leakage.
    • This innovation broadens the scope of indications treatable with fiber-based PDT.