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Co-infections with hepatitis G and TT virus in patients with chronic hepatitis C in Hungary

A Pár1, Mária Takács, Judit Brojnás

  • 1First Department of Medicine, Medical Faculty, University of Pécs, Ifjúság ut 13, H-7624 Pécs, Hungary.

Acta Microbiologica Et Immunologica Hungarica
|February 12, 2005
PubMed

Insights

Co-infections with Hepatitis G virus (HGV) and TT virus (TTV) do not significantly alter chronic hepatitis C (HCV) progression. Interferon (IFN) treatment showed a potential antiviral effect on TTV in patients with sustained HCV remission.

Area of Science:

  • Hepatology
  • Virology
  • Infectious Diseases

Background:

  • The role of co-infections with Hepatitis G virus (GBV-C, HGV) and TT virus (TTV) in chronic hepatitis C (HCV) remains unclear.
  • Understanding these co-infections is crucial for managing HCV patients.

Purpose of the Study:

  • To determine the prevalence of HGV RNA and TTV DNA in chronic hepatitis C patients and asymptomatic HCV carriers.
  • To assess the impact of HGV and TTV on the course of HCV infection.
  • To investigate the influence of interferon (IFN) therapy on these co-infections.

Main Methods:

  • Polymerase Chain Reaction (PCR) was used to detect HGV RNA and TTV DNA.
  • Serum samples from 77 chronic hepatitis C patients (50 treated with IFN) and 33 asymptomatic HCV carriers were analyzed.
  • Previous Hepatitis B virus (HBV) infection was assessed using HBsAg and aHBc testing.

Main Results:

  • In the general population, HGV RNA prevalence was 8.0% and TTV DNA was 18.5%.
  • In chronic hepatitis C patients, HGV RNA was found in 9.09% and TTV DNA in 40.25%.
  • TTV DNA was less frequent (20%) in IFN-treated patients with sustained remission compared to non-responders (45.7%). Asymptomatic HCV carriers showed 9.09% HGV RNA and 75.7% TTV DNA.

Conclusions:

  • Neither HGV RNA nor TTV DNA demonstrated a significant effect on the progression of HCV infection.
  • The lower frequency of TTV in patients achieving sustained remission with IFN suggests a potential antiviral effect of IFN on TTV.
  • Further research is needed to fully elucidate the clinical significance of these co-infections in chronic hepatitis C.

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