Related Experiment Videos
[Atypical antipsychotics in the elderly]
1Klinisch geriater, afdeling geriatrie, Psycho Medisch Centrum Parnassia, Den Haag. E.van.Melick@Parnassia.nl
Tijdschrift Voor Gerontologie En Geriatrie
|February 12, 2005
Summary
Atypical antipsychotics, like clozapine, are effective for Parkinson psychosis with fewer motor side effects. While evidence is limited for some, they generally show efficacy and reduced tardive dyskinesia risk in elderly patients.
Area of Science:
- Pharmacology
- Neuroscience
Context:
- Atypical antipsychotics are defined by efficacy and minimal extrapyramidal symptoms (EPS), distinguishing them from traditional antipsychotics.
- Clozapine exhibits the most atypical properties, demonstrating efficacy in Parkinson psychosis with minimal motor adverse effects.
Purpose:
- To differentiate atypical antipsychotics from traditional ones based on efficacy and EPS.
- To evaluate the efficacy and safety of atypical antipsychotics, including clozapine, quetiapine, risperidone, and olanzapine, particularly in elderly patients and specific conditions like Parkinson psychosis and dementia.
Summary:
- Clozapine is the preferred atypical antipsychotic for Parkinson psychosis due to its efficacy and minimal motor side effects.
- Risperidone and olanzapine show dose-dependent Dopamine2-occupancy and potential for EPS, though less than traditional antipsychotics.
- All discussed atypical antipsychotics are associated with a lower incidence of tardive dyskinesia.
- Atypical antipsychotics are likely as effective as traditional ones in elderly patients with functional psychosis, with lower median daily doses.
- Risperidone is effective for managing aggressive behavior in dementia.
Impact:
- Clozapine offers a superior treatment option for Parkinson psychosis, improving motor function.
- Atypical antipsychotics present a potentially safer alternative for elderly patients with functional psychosis, requiring careful consideration of their specific adverse effects.
- Risperidone demonstrates efficacy in managing behavioral disturbances in dementia patients.