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Updated: Mar 2, 2026

Yeast As a Chassis for Developing Functional Assays to Study Human P53
Published on: August 4, 2019
[p53 gene codon 72 polymorphism and susceptibility to keloid in Chinese population]
Yang Zhuo1, Jianhua Gao, Shenqiu Luo
1Department of Plastic Surgery, Nanfang Hospital, Southern Medical University (the First Military Medical University), Guangzhou Guangdong 510515, PR China.
Objective:
To investigate the relationship between p53 codon 72 polymorphism and susceptibility to keloid.
Methods:
The p53 genotypes were detected by polymerase chain reaction-reverse dot blot (PCR-RDB) and DNA direct sequencing among 15 healthy controls and 15 patients with keloid.
Results:
The frequency of the Pro allele (P = 0.035) and Pro/Pro genotype (P = 0.030) in patients was significantly higher than that in the controls. There was no significant difference in the frequency of Pro/Arg and Arg/Arg genotypes between patients and controls.
Conclusion:
The p53 gene codon 72 polymorphism may play a role in susceptibility to keloid.
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