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Updated: Aug 17, 2026

Murine Dermal Fibroblast Isolation by FACS
Published on: January 7, 2016
[The role of myofibroblast in the development of pathological scar]
Objective:
To study the effect of myofibroblast on the development of pathological scar.
Methods:
From 1998 to 2000, 14 cases of keloid(k), 13 cases of hypertrophic scar(HS), and 7 cases of scar were studied through immunohistochemistry and electron microscope.
Results:
Myofibroblasts were often observed in the hypertrophic HS by electron microscope, but no myofibroblast was observed in the K and NS. alpha-SM-actin was expressed in fibroblast of HS, but was not expressed in K and NS.
Conclusion:
Myofibroblast may play a role in the development of hypertrophic scar. The difference between the absence of myofibroblast in keloid and the invasion of keloid deserves further study.
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