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Historical comments on tardive dyskinesia: a neurologist's perspective
1Department of Neurology, The Ohio State University, Columbus, OH 43210, USA. paulson.2@osu.edu
The Journal of Clinical Psychiatry
|February 12, 2005
Summary
Tardive dyskinesia (TD) was initially unrecognized due to unfamiliarity with delayed drug reactions. Increased professional awareness has since occurred, though challenges in treatment and understanding TD
Area of Science:
- Neurology
- Pharmacology
- Psychiatry
Background:
- Review of the historical professional awareness of tardive dyskinesia (TD).
- Exploration of the reasons behind the delayed recognition of TD.
- Emphasis on personal recollections to illustrate the phenomenon of discovery.
Observation:
- Physicians were initially unaware of delayed drug reactions like TD.
- The presentation of drug side effects was not understood in the context of TD.
- Early recognition of TD was hampered by a lack of understanding of its delayed onset and presentation.
Findings:
- Tardive dyskinesia (TD) is now widely recognized by psychiatrists, neurologists, and general practitioners.
- Personal experiences highlight the evolution from uncertainty to widespread awareness of TD.
- The historical delay in recognizing TD and its underlying causes remain subjects of interest.
Implications:
- TD has significantly altered our understanding of disease causation.
- It highlights the potential for beneficial agents to cause deleterious late effects.
- Ongoing challenges include developing effective therapies and fully elucidating the pathophysiology of TD.