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Published on: June 2, 2014
Effect of low-intensity acenocoumarol on frequency and severity of migraine attacks
Elisabeth A Wammes-van der Heijden1, Martijn H Smidt, Cees C Tijssen
1Utrecht Institute for Pharmaceutical Sciences, Pharmacoepidemiology and Pharmacotherapy, Utrecht, The Netherlands.
Objective:
To investigate the effect of low-intensity acenocoumarol treatment (target INR 1.5 to 2.0) on the frequency and severity of migraine attacks.
Background:
The positive effect of anticoagulation on migraine has been described in case reports and observational studies.
Methods:
We conducted a randomized, open, crossover study in migraine patients. After a run-in period of 8 weeks, all patients received acenocoumarol or propranolol during a period of 12 weeks and, after a washout period of 2 weeks, propranolol or acenocoumarol during a second period of 12 weeks.
Results:
Nineteen patients fulfilling the criteria were included. In 12 patients with complete data collection, only one good responder could be noted. In the other patients, treatment with low-intensity acenocoumarol did not show improvement of migraine symptoms compared with the run-in period. Treatment with propranolol showed a trend towards improvement compared with the run-in period. No serious adverse events were observed.
Conclusions:
Overall, low-intensity acenocoumarol treatment has no prophylactic effect in migraine patients.
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