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Updated: Aug 12, 2026

Bronchial Thermoplasty: A Novel Therapeutic Approach to Severe Asthma
Published on: November 4, 2010
Correlation of exhaled breath temperature with bronchial blood flow in asthma
Paolo Paredi1, Sergei A Kharitonov, Peter J Barnes
1Department of Thoracic Medicine, National Heart and Lung Institute, Faculty of Medicine, Imperial College, London, UK. p.paredi@imperial.ac.uk
Abstract:
In asthma elevated rates of exhaled breath temperature changes (Deltae degrees T) and bronchial blood flow (Qaw) may be due to increased vascularity of the airway mucosa as a result of inflammation.We investigated the relationship of Deltae degrees T with Qaw and airway inflammation as assessed by exhaled nitric oxide (NO). We also studied the anti-inflammatory and vasoactive effects of inhaled corticosteroid and beta2-agonist.Deltae degrees T was confirmed to be elevated (7.27 +/- 0.6 Delta degrees C/s) in 19 asthmatic subjects (mean age +/- SEM, 40 +/- 6 yr; 6 male, FEV1 74 +/- 6 % predicted) compared to 16 normal volunteers (4.23 +/- 0.41 Delta degrees C/s, p < 0.01) (30 +/- 2 yr) and was significantly increased after salbutamol inhalation in normal subjects (7.8 +/- 0.6 Delta degrees C/ s, p < 0.05) but not in asthmatic patients. Qaw, measured using an acetylene dilution method was also elevated in patients with asthma compared to normal subjects (49.47 +/- 2.06 and 31.56 +/- 1.6 mul/ml/min p < 0.01) and correlated with exhaled NO (r = 0.57, p < 0.05) and Deltae degrees T (r = 0.525, p < 0.05). In asthma patients, Qaw was reduced 30 minutes after the inhalation of budesonide 400 mug (21.0 +/- 2.3 mul/ml/min, p < 0.05) but was not affected by salbutamol.Deltae degrees T correlates with Qaw and exhaled NO in asthmatic patients and therefore may reflect airway inflammation, as confirmed by the rapid response to steroids.
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