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Updated: Aug 19, 2026
Semiconductor Sequencing for Preimplantation Genetic Testing for Aneuploidy
Published on: August 25, 2019
Preimplantation genetic diagnosis for aneuploidy screening in patients with unexplained recurrent miscarriages
Peter Platteau1, Catherine Staessen, An Michiels
1Center for Reproductive Medicine, University Hospital, Dutch-speaking Brussels Free University (Vrije Universiteit Brussel), Brussels, Belgium. peter.platteau@az.vub.ac.be
Objective:
To determine the aneuploidy rate in embryos of women with idiopathic recurrent miscarriages and to evaluate whether preimplantation genetic diagnosis for aneuploidy screening could be a feasible approach to improve the possibility of successful pregnancy in these couples.
Design:
Prospective cohort study.
Setting:
Tertiary university referral center.
Patient(S):
Women (n = 49) with recurrent idiopathic miscarriages.
Intervention(S):
In vitro fertilization with preimplantation genetic diagnosis for aneuploidy screening.
Main Outcome Measure(S):
Ongoing pregnancy rate (PR) and aneuploidy rate.
Result(S):
The aneuploidy rate was, respectively, 43.85% and 66.95% in the younger and older group. The ongoing PR per cycle was 25.71% in the younger and 2.94% in the older patients.
Conclusion(S):
There is no therapeutic evidence to prescribe IVF with or without preimplantation genetic diagnosis for aneuploidy screening for this heterogeneous group of patients.
